Drostanolone propionate (Masteron) was first described in 1959. This injectable drug was developed by Syntex along with other products such as oxymetholone and methyl drostanolone. Despite the fact, it hit the market a decade later. Lilly and Syntex agreed upon collaboration in introduction of the product. Lilly was selling drostanolone propionate in the US by the Drolban brand name while Syntex was distributing it in other markets.

Masteron Drostanolone was widely used by athletes in the 70-80's, however, in healthcare there were some restrictions of administration. With the advent of other methods of breast cancer treatment the drostanolone production first dropped and later stopped at all, so the product gradually disappeared from the market.

Chemical Structure

Masteron Drostanolone propionate is an anabolic (known as dromostanolone), modified form of dihydrotestosterone. The difference is in a methyl group added in 2alpha position, which enhances the anabolic steroid strength, increasing metabolism resistance of 3a-hydroxysteroid dehydrogenase enzyme in muscle tissue (2alpha,5alpha,17beta)-17-Hydroxy- 2-metilandrostan-3-one formula C20H32O2.

Masteron Drostanolonedipropionate is a modified form of drostanolonewith a propionate ester attached to the 17-beta hydroxyl group. In contrast to free steroids, esterified steroids are less polar, so they are slower absorbed from the injection site.


  • It is anabolic steroid produced in the form of propionateether and enanthateether.
  • It has high androgenic activity and moderate anabolic effect.
  • It is non-aromatizing (i.e. it doesn’t turn to estrogen), quite the opposite, it is an aromatase inhibitor.
  • It does not cause fluid retention and has mild diuretic effect.
  • A cycle of Masteron can reduce fat mass by 5-7%.
  • Masteron can boost one’s power performance while maintaining weight and reducing fat mass.


  • Masteron Drostanolone propionate is widely used by athletes in bodybuilding to preserve muscle mass and strength during “cutting phase”.
  • Drostanolone is often used by runners and athletes who are willing to stay in the same weight category (to avoid mass gain).
  • Masteron is popular in bodybuilding as it doesn’t cause water retention and has mild diuretic effect, which, in turn, helps to get rippling muscles.
  • Drostanolone may be interesting for those athletes who are eager to increase muscle hardness and density. The product is usually used shortly before a competition.
  • Drostanolone makes it possible to achieve the best possible muscle forms. Its fat-burning properties contribute to the process as well.
  • Experience has shown that a cycle of Masteron can reduce fat mass by 5-7%.
  • Masteron enhances physical performance while maintaining weight and reducing fat mass. This effect of drostanolone especially attracts powerlifters.
  • The product can be used along with a diet to lose weight while maintaining muscle mass and suppressing catabolism

Masteron Side effects

  • Due to a low anabolic index Masteron is a good fat-burner. At the same time it increases the risk of androgenic side effects such as aggression, acne, baldness, prostate hypertrophy and virilization in women.
  • Masterondoesn’t cause water retention or high blood pressure and has low toxicity to the liver.
  • Once, the female swimming team from Eastern Germany received almost all gold medals in Olympic Games. Later it was proved that female athletes had used a derivative of dihydrotestosterone, and obviously it was Masteron. During the interview a reporter asked why all the female athletes have such a low voice? The answer was that they were here to swim, not sing.

Masteron Dosages and Uses

Optimal effect is achieved with the dosage of 400-500mg a week.

Dosage increase doesn’t reasonably improve the results. Taking into account short chain of propionate, drostanolone propionate must be used 3 times a week (or every other day).

Masteron Cycles (Courses)

Drostanolone combinability

Due to the high affinity to the androgen receptor and its androgenic properties, it is recommended to combine this drug with the steroids such as Winstrol or Oxandrolone. Winstrol is less active in interaction with androgen receptors and decreases globulin concentration, so the combination will have expressed synergistic effect during“cutting phase”.

For mass gain it is recommended to combine Masteron and Testosterone Propionate, but in this case testosterone production is highly suppressed. That’s why during long cycles it is necessary to apply gonadotropin. Besides, Masteron works fine with Trenbolone or Boldenone.