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Clenbuterol

Clenbuterol is powerful fat burning agent, which is a good addition to any cutting cycle. Stack well with T3, Cardarine and T4. Use with Ketotifen to reduce side effects and extend Clen cycle duration. 20-40 mcg/day 4-6 weeks

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    Clenbuterol is powerful fat burning agent, which is a good addition to any cutting cycle.

    • Powerful Fat Burning
    • Improves Performance
    • Retains Lean Muscle
    • Usage: 20-120 mcg/day
    • Cycle Duration: 4-6 weeks for optimal results 
    • On Cycle Therapy: Use with Ketotifen to reduce side effects and extend Clen cycle duration.
    • Stack With: Stack well with T3, Cardarine and T4.

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    Clenbuterol is powerful fat burning agent, which is a good addition to any cutting cycle.

    • Powerful Fat Burning
    • Improves Performance
    • Retains Lean Muscle
    • Usage: 20-120 mcg/day
    • Cycle Duration: 4-6 weeks for optimal results 
    • On Cycle Therapy: Use with Ketotifen to reduce side effects and extend Clen cycle duration.
    • Stack With: Stack well with T3, Cardarine and T4.

    Increases Strength

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    Ketotifen (Removes Clen Side Effects) 1mg/100tabs - Apoxar

    Ketotifen is an antihistimine that inhibits down regulation of beta receptors, which are often degraded by fat-burners such as Albuterol and Clenbuterol.

    • Ketotifen fumarate alleviates allergy symptoms and asthma.
    • Removes Clen side effects: trembling hands, high blood pressure, nausea.
    • Use with Clenbuterol or Albuterol to increase effectiveness and duration of the cycle.
    • Usage: 1mg for 100mcg of Clen per day

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What is Clenbuterol

Clenbuterol was created for asthma treatment and originally wasn’t meant to do anything with bodybuilding. But soon after it was released to the public, athletes found out that they can use Clenbuterol for weight loss. Nowadays most people who buy Clenbuterol in Canada seek extra results for their cutting cycle and not a treatment for asthma.

How Clenbuterol Works

There are two types of adrenoreceptors in muscle tissues - Alpha and Beta. Alpha receptors are responsible for gaining and storing fat. Beta receptors, on the contrary, start fat burning processes in your organism. Clenbuterol is a beta-2-agonist. It activates Beta receptors, which results in boosted metabolism and fat breakdown. Clenbuterol also affects your thyroid gland and enhances the production of fat-burning hormones.

 Clenbuterol Benefits

  • Fast weight loss
  • Energy boost
  • Enhanced metabolism (up to 30%)
  • Dry muscle mass
  • Decreased appetite

Clenbuterol Dosage

For the best cutting cycle, athletes start with 20mg and add 15-20mg daily in the first week. It’s not recommended to exceed the maximum safe Clenbuterol dosage of 120mg.

Clenbuterol Cycle

The duration of the Clenbuterol cycle is about 1,5 months or 6 weeks. In the first two weeks, you can take a clenbuterol solo. From day 14 it’s important to either take a 2-weeks break OR add a support drug Ketotifen, because your receptors become unresponsive to Clenbuterol, and Ketotifen prolongs the effect. During the break, Ketotifen is necessary as well, without it the pause in your cycle should last up to 4-6 weeks instead of 2. Given the known Clenbuterol dosage, the most common cycle would look like this:

  • Clenbuterol Weight Loss Cycle;
  • Day 1: Clenbuterol 20mg daily
  • Day 2: Clenbuterol 35-40mcg daily
  • Day 3: Clenbuterol 50-60mcg daily
  • Day 4: Clenbuterol 50-60mcg daily
  • Day 5: Clenbuterol 65-80mcg daily
  • Day 6: Clenbuterol 80-100 mcg daily
  • Day 7: Clenbuterol 100-120mcg daily
  • Week 2: Clenbuterol 100-120mcg daily
  • Weeks 3-4: Clenbuterol 100-120mcg + Ketotifen 1-2mg daily
  • Week 5: Clenbuterol 80-100 mcg + Ketotifen 1-2mg daily
  • Week 6: Clenbuterol 65-80mcg daily + Ketotifen 1-2mg daily

If you’re not comfortable with taking the compound on a daily basis, there is another common option - on and off the Clenbuterol cycle. Just take the drug once in two days instead of every day and still get all the benefits of it. This method does not affect the result, just the time that it takes you to achieve it.

Clenbuterol For Women

Clenbuterol is technically not a steroid, it has no androgenic side effects, and therefore - safe for female athletes. Clenbuterol cycle for women is the same as it is for men, though the dosage should not exceed over 100mg. Female athletes typically get all the benefits of Clenbuterol and report a significant weight loss after the cycle.

Clenbuterol Side Effects

Clenbuterol has little side effects, none of which are irreversible. Most of it appears in the first days of the cycle and either fade away either by the end of the first week or get eliminated by Ketotifen. Here is what you have to know about the most common Clenbuterol side effects:

Blood pressure and sped up the heartbeat

Reported by over 50% of athletes. To counter it, you can add 5 mg of Bisoprolol or 50 mg of Metoprolol in the morning during the cycle.

Trembling

Experienced by 1 in 5 athletes. Especially notable on the first day of the Clenbuterol cycle.

While that’s typically all you can expect, here is a list of other side effects that are proven to exist, but are experienced by less than 10% of the athletes:

  • Sweating
  • Insomnia
  • Anxiety
  • Nausea
  • Nervousness
  • Muscle cramps

Clenbuterol reviews

Clenbuterol has been on the market for quite a long time now, from the 1970s, and most reviews by athletes give you a sense of what exactly to expect from it. Here is what Clenbuterol can give you and some tricky details you might have never thought about.

  • Clenbuterol can help you to lose about 5-7% of body fat, or around 17-22lbs loss by the end of the cycle.
  • Don’t expect your muscles to grow. It’s a cutting steroid, not suitable for your bulking cycle. Clenbuterol reviews that mention the anabolic effect are based on veterinary surveys and high doses of intake. It’s still a debatable issue among bodybuilders, while the fat burning effect of Clenbuterol is medically proven.
  • Maintain a proper diet. Clenbuterol is not a magic pill, you definitely need to avoid junk food, lower your calorie intake, and keep your daily ratio low on carbs.
  • For lean muscle and shredded look most athletes add BCAA and protein shakes to the cycle.
  • Eat more bananas! Clenbuterol is known to lower your natural potassium levels, and bananas are the best source of it out there.

Fake Clenbuterol Warning!

Clenbuterol is not a steroid, it's legal and there is a plenty of farm-grade Clenbuterol available on the market. But since it has become so popular in the bodybuilding community, some stores sell fake compound, and Canada is, unfortunately, not the exception. When you buy Clenbuterol in Canada, make sure that one tablet contains from 20 to 50mcg (the most common Clenbuterol dosage) and make sure that you get your tablets from a legit manufacturer.

Clenbuterol Description

Clenbuterol hydrochloride is an anti-asthma medication that belongs to a broad group of drugs knows as sympathomimetics. These drugs affect the sympathetic nervous system in a wide number of ways, largely mediated by the distribution of adrenoceptors. There are actually nine different types of these receptors in the body, which are classified as either alpha or beta and further subcategorized by type number. Depending on the specific affinities of these agents for the various receptors, they can potentially be used in the treatment of conditions such as asthma, hypertension, cardiovascular shock, arrhythmias, migraine headaches, and anaphylactic shock. The text Goodman and Gillman’s The Pharmacological Basis of Therapeutics 9th edition does a good job of describing the diverse nature in which these drugs affect the body:

Most of the actions of catecholamines and sympathomimetic agents can be classified into seven broad types:

  1. peripheral excitatory action on certain types of smooth muscles such as those in blood vessels supplying the skin, kidney, and mucous membranes, and on the gland cells, such as those of the salivary and sweat glands;
  2. a peripheral inhibitory action on certain other types of smooth muscle, such as those in the wall of the gut, in the bronchial tree, and in blood vessels supplying skeletal muscle;
  3. a cardiac excitatory action, responsible for an increase in heart rate and force of contraction;
  4. metabolic actions, such as an increase in the rate of glycogenolysis in liver and muscle and liberation of free fatty acids from adipose tissue;
  5. endocrine actions, such as modulation of the secretion of insulin, rennin, and pituitary hormones;
  6. CNS actions, such as respiratory stimulation and, with some of the drugs, an increase in wakefulness and psychomotor activity and a reduction in appetite;
  7. presynaptic actions that result in either inhibition or facilitation of the release of the neurotransmitters such as norepinephrine and acetylcholine.

Clenbuterol hydrochloride is specifically a selective beta-2 sympathomimetic, primarily affecting only one of the three subsets of beta-receptors. Of particular interest is the fact that this drug has little beta-1 stimulating activity. Since beta-1 receptors are closely tied to the cardiac effects of these agents, this allows clenbuterol hydrochloride to reduce reversible airway obstruction (an effect of beta-2 stimulation) with much less cardiovascular side effects compared to non-selective beta-agonists. Clinical studies with this drug show it is extremely effective as a bronchodilator, with a low level of user complaints and high patient compliance.¹ Clenbuterol hydrochloride also exhibits an extremely long half-life in the body, which is measured to be approximately 34 hours long. This makes steady blood levels easy to achieve, requiring only a single or twice-daily dosing schedule at most. This, of course, makes it much easier for the patient to use and may tie into its high compliance rate.

In animal studies clenbuterol hydrochloride is shown to exhibit anabolic activity, obviously an attractive trait to a bodybuilder or athlete. This compound is additionally a known thermogenic, with beta-2 agonists like clenbuterol hydrochloride shown to directly stimulate fat cells and accelerate the breakdown of triglycerides to form free fatty acids.² Its efficacy in this area makes clenbuterol hydrochloride a very popular fat loss drug among the bodybuilding community. Those interested in this drug are often hoping it will produce a little of both benefits, promoting the loss of body fat while imparting increases in strength and muscle mass. But as was well pointed out by a review published in the August 1995 issue of medicine and Science in Sports and Exercise, the possible anabolic results in humans are very questionable and based only on animal data using much larger doses than would be required for bronchodilation. With such reports, there has been a lot of debate as to whether or not clenbuterol hydrochloride is really anabolic in humans at all. Some seem to swear by the fact that it builds muscle, and use clenbuterol hydrochloride regularly as an off-season or adjunct anabolic. To others, the MSSE report is confirmation that athletes have wasted valuable time and money on drugs that do not build muscle. The debate over clenbuterol hydrochloride’s potential anabolic activity continues today.

History

Clenbuterol hydrochloride has been available as a bronchodilator for decades and is widely used in many parts of the world. Although it has a good safety record and approval in a wide number of other countries, this compound has never been made available for human use in the United States. The fact that there are a number of similar effective asthma medications already approved by the FDA and available may have something to do with this, as a prospective drug firm would likely not find it a profitable enough product to warrant undergoing the expense of the new drug approval process. Regardless of this fact, foreign clenbuterol hydrochloride preparations are popular among U.S. bodybuilders and athletes, and today are widely available on the black market. Note that in recent years, clenbuterol overdose/poisoning has been reported in a number of people, striking up a great deal of controversy about the safety of this drug and its off-label use for physique- and performance-enhancing purposes.

How Supplied

Clenbuterol hydrochloride is most commonly supplied in oral tablets of 20mcg each. It is also supplied in oral syrups, injectable solutions, and for inhalation use.

Structural Characteristics

Clenbuterol hydrochloride is a long-acting selective ‚2- adrenergic receptor agonist. It has the chemical designation 1-(4-amino-3,5-dichloro-phenyl)-2-(tertbutylamino) ethanol.

Side Effects

The possible side effects of clenbuterol hydrochloride include those of other CNS stimulants, and include such occurrences as shaky hands, insomnia, sweating, increased blood pressure, and nausea. These side effects will generally subside after a week or so of use, once the user becomes accustomed to the drug. Clenbuterol hydrochloride is a CNS stimulant with the potential for a fatal overdose. Signs of overdose may include rapid breathing, blood pressure irregularities, irregular heartbeat, unconsciousness, trembling, shaking, panic, extreme restlessness, and severe nausea, vomiting, or diarrhea.

Administration

When used for the management of asthma, the most common clinical dose for adults is 20mcg (1 tablet) twice per day. Some patients require up to 40mcg (2 tablets) twice per day. When using the drug (off-label) for physique- or performance-enhancing purposes, bodybuilders and athletes generally tailor their dosage and cycling of this product based on personal sensitivity to its benefits and side effects. To accomplish this, one often begins a cycle by taking one or two tablets per day, and gradually increasing the dosage every third day by one half to 1 tablet until the desired dosage range is established. At peak therapy, some users can tolerate as many as 6-8 tablets per day (120-160mcg). Given the potency and potential for serious side effects, however, any dosage outside of the normal therapeutic range should be approached with an even greater level of caution.

The drug will usually elevate the body temperature shortly after therapy is initiated. The rise in temperature is commonly .5 to 1 degree, sometimes a little more. This elevation is due to one’s body burning excess energy (largely from fat) and is usually not uncomfortable. The number of consecutive days clenbuterol hydrochloride is now used is usually dependent on the response of the individual. To be clear, the athletic benefits of this drug will only last for a limited time and then diminish, largely due to beta-receptor downregulation. By most accounts, clenbuterol hydrochloride seems to work well for approximately 4 to 6 weeks. During this period, users generally monitor their body temperature on a regular basis. We are given some level of assurance that clenbuterol hydrochloride is working by the temperature elevation. Once the temperature drops back to normal, receptor downregulation has probably diminished the efficacy of the drug. At this point increasing the dosage is usually not regarded as effective, and instead, clenbuterol hydrochloride is discontinued for a period of no less than 4-6 weeks.

Many bodybuilding competitors enhance the fat burning effect of clenbuterol hydrochloride with the use of additional substances. Many have commented that when the drug is combined with thyroid hormones, specifically the powerful Cytomel®, the thermogenic effect can become extremely dramatic. Such a mix is often further used during a steroid cycle, helping the individual elicit a much more toned physique from the drugs. A clenbuterol/thyroid mix is also common when using growth hormone, which is believed to enhance the thermogenic and anabolic effect of HGH therapy. Lastly, ketotifen has also been a popular adjunct to clenbuterol hydrochloride, which is an antihistamine that upregulates beta-2 receptor density. It seems capable of not only increasing the potency of each dose of clenbuterol hydrochloride (allowing the user to take less clenbuterol) but also of perhaps even slowing receptor downregulation (see the Ketotifen profile for a more comprehensive discussion).

Availability

Clenbuterol hydrochloride is readily available on the international market. Although it is usually a very cheap drug in common source countries, allowing black market dealers ample opportunity to obtain legitimate drugs to divert for sale, clenbuterol hydrochloride has been the subject of low-level counterfeiting.

References:

  1. Clenbuterol and salbutamol in the symptomatic treatment of patients with reversible airways obstruction. Jaffé G, Grimshaw JJ. Pharmatherapeutica. 1983;3(7):492-5.
  2. Effect of clenbuterol on apoptosis, adipogenesis, and lipolysis in adipocytes. Kim HK, Della-Fera MA, Hausman DB, Baile CA. J Physiol Biochem. 2010 Sep;66(3):197-203.

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