There are loads of NSAIDs in the market. Even though they work to relieve pain and inflammation, there are differences. All of the NSAIDs inhibit cyclo-oxygenase enzyme. This is what leads to decrease in thromboxane and prostaglandins synthesis. However, not all of this NSAIDs qualify as organic acids. 

All of the NSAIDs inhibit COX-I and 2. The mode of inhibition varies though with the chemical categories. COX-1 is present in many tissues. In the gastrointestinal tract, it maintains the lining of the intestines and stomach. COX 1 has been reported to have an active role in platelet and kidney function. COX 2 is only present at inflammation sites.

Even though the COX 2 and 1 have a part in conversion or arachdonic acid to form prostaglandins in relieve of inflammation and pain, there are negative effective. Some functions make inhibition of COX-1 undesirable while inhibition of COX 2 is considered to be desirable.


Diclofenac has antipyretic, anti-inflammatory and analgesic properties. It is effective in treating chronic and acute pain. It also reduces inflammation. The effects diclofenac has in the body systems include:

  • Inhibition of lipoxygenase enzymes
  • Activation of nitric oxide-cGMP antinociceptive pathway
  • Inhibition of thromboxane-prostanoid receptor
  • Inhibition of substrate P
  • Altering interleukin-6 production.

Diclofenac relieves pain in patients suffering from headache, rheumatoid arthritis and osteoarthritis and hip degenerative diseases. 


Celebrex is an NSAID, which has selective inhibition of the COX 2. This makes it the best choice in patients who are at risk of GI bleeding.  It has antipyretic, analgesic and anti-inflammatory properties. It also has potent inhibition in synthesis of prostaglandins in vitro.

The main route of excretion of the drug is through the hepatic system. Some traces of the drug are excreted in urine. Therefore, it is not advisable for patients with liver conditions or failure to take celebrex in high doses. It relieves pain associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and primary dysmenorrhea

Whether diclofenac is better compared to celebrex depends on the medical history of the patient and the use it is intended for. Diclofenac is more available and cheap compared to celebrex. However, patients who have GI bleeding should always go for celebrex especially if they will need the analgesia for a long term use. Prolonged use of NSAIDs increases the risk of stroke and heart attacks. Patients who have underlying cardiac conditions are at a higher risk. A prescription should be obtained from a doctor after a careful medical history has been taken to rule out contraindications.